Potentiation of the cataleptic effect of morphine and clonidine by amodiaquine in mice.
نویسندگان
چکیده
Muley et al. (8) and Jadhav et al. (2) have recently shown histamine to be responsible for the cataleptic effect of morphine and clonidine in mice. Since amodiaquine is reported to inhibit histarnine-Nvrnethvl transferase, an enzyme concerned with major, catabolism of brain histamine by methylation (4), we have investigated the effect of pretreatment with amodiaquine on morphine-and clonidine-induced catalepsy in mice.
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ورودعنوان ژورنال:
- Indian journal of physiology and pharmacology
دوره 28 4 شماره
صفحات -
تاریخ انتشار 1984